The presence of an unpaired electron results in certain common properties that are shared by most radicals. The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases.Ī free radical can be defined as any molecular species capable of independent existence that contains an unpaired electron in an atomic orbital. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Hence application of external source of antioxidants can assist in coping this oxidative stress. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. A balance between free radicals and antioxidants is necessary for proper physiological function. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. In recent years, there has been a great deal of attention toward the field of free radical chemistry.
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